Since 2017, Louisville and Virginia Tech have met 3 times, with Louisville holding a 2–1 edge in the series.
Most recently Louisville won 28–16 on November 1, 2025.
Right now Louisville is 2–3 and Virginia Tech is 4–1, with Louisville at 17 days since a win against Virginia Tech's 10.
| Date | Site | Winner | Score |
|---|---|---|---|
| Sat, Nov 1 2025 | Virginia Tech home | Louisville | 28–16 |
| Sat, Nov 4 2023 | Louisville home | Louisville | 34–3 |
| Sat, Oct 31 2020 | Louisville home | Virginia Tech | 42–35 |
Full schedules and drought counters: Louisville Cardinals and Virginia Tech Hokies.
Louisville vs Boston College, Louisville vs California, Louisville vs Clemson, Louisville vs Duke, Louisville vs Florida State, Louisville vs Georgia Tech, Louisville vs Miami, Louisville vs NC State, Louisville vs North Carolina, Louisville vs Pitt, Louisville vs SMU, Louisville vs Stanford, Louisville vs Syracuse, Louisville vs Virginia, Louisville vs Wake Forest.
Virginia Tech vs Boston College, Virginia Tech vs California, Virginia Tech vs Clemson, Virginia Tech vs Duke, Virginia Tech vs Florida State, Virginia Tech vs Georgia Tech, Virginia Tech vs Miami, Virginia Tech vs NC State, Virginia Tech vs North Carolina, Virginia Tech vs Pitt, Virginia Tech vs SMU, Virginia Tech vs Stanford, Virginia Tech vs Syracuse, Virginia Tech vs Virginia, Virginia Tech vs Wake Forest.