Since 2017, Clemson and Louisville have met 7 times, with Clemson holding a 6–1 edge in the series.
Most recently Clemson won 20–19 on November 14, 2025.
Right now Clemson is 3–2 and Louisville is 2–3, with Louisville at 17 days since a win against Clemson's 11.
| Date | Site | Winner | Score |
|---|---|---|---|
| Fri, Nov 14 2025 | Louisville home | Clemson | 20–19 |
| Sat, Nov 2 2024 | Clemson home | Louisville | 33–21 |
| Sat, Nov 12 2022 | Clemson home | Clemson | 31–16 |
| Sat, Nov 6 2021 | Louisville home | Clemson | 30–24 |
| Sat, Oct 19 2019 | Louisville home | Clemson | 45–10 |
| Sat, Nov 3 2018 | Clemson home | Clemson | 77–16 |
| Sat, Sep 16 2017 | Louisville home | Clemson | 47–21 |
Full schedules and drought counters: Clemson Tigers and Louisville Cardinals.
Clemson vs Boston College, Clemson vs California, Clemson vs Duke, Clemson vs Florida State, Clemson vs Georgia Tech, Clemson vs Miami, Clemson vs NC State, Clemson vs North Carolina, Clemson vs Pitt, Clemson vs SMU, Clemson vs Stanford, Clemson vs Syracuse, Clemson vs Virginia, Clemson vs Virginia Tech, Clemson vs Wake Forest.
Louisville vs Boston College, Louisville vs California, Louisville vs Duke, Louisville vs Florida State, Louisville vs Georgia Tech, Louisville vs Miami, Louisville vs NC State, Louisville vs North Carolina, Louisville vs Pitt, Louisville vs SMU, Louisville vs Stanford, Louisville vs Syracuse, Louisville vs Virginia, Louisville vs Virginia Tech, Louisville vs Wake Forest.