Since 2017, Michigan State and USC have met 1 time, and USC has the better of it at 1–0.
Most recently USC won 45–31 on September 20, 2025.
Right now Michigan State is 2–3 and USC is 5–1, with Michigan State at 24 days since a win against USC's 3.
| Date | Site | Winner | Score |
|---|---|---|---|
| Sat, Sep 20 2025 | USC home | USC | 45–31 |
Full schedules and drought counters: Michigan State Spartans and USC Trojans.
Michigan State vs Illinois, Michigan State vs Indiana, Michigan State vs Iowa, Michigan State vs Maryland, Michigan State vs Michigan, Michigan State vs Minnesota, Michigan State vs Nebraska, Michigan State vs Northwestern, Michigan State vs Ohio State, Michigan State vs Oregon, Michigan State vs Penn State, Michigan State vs Purdue, Michigan State vs Rutgers, Michigan State vs UCLA, Michigan State vs Washington, Michigan State vs Wisconsin.
USC vs Illinois, USC vs Indiana, USC vs Iowa, USC vs Maryland, USC vs Michigan, USC vs Minnesota, USC vs Nebraska, USC vs Northwestern, USC vs Ohio State, USC vs Oregon, USC vs Penn State, USC vs Purdue, USC vs Rutgers, USC vs UCLA, USC vs Washington, USC vs Wisconsin.